SpringerOpen Newsletter

Receive periodic news and updates relating to SpringerOpen.

Open Access Highly Accessed Open Badges Review

Costing of physical activity programmes in primary prevention: a review of the literature

Silke B Wolfenstetter1 and Christina M Wenig12*

Author Affiliations

1 Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Health Economics and Health Care Management, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany

2 Ludwig-Maximilians-Universität München, Institute of Health Economics and Health Care Management and Munich Center of Health Sciences, Ludwigstr. 28 RG, 80539 Munich, Germany

For all author emails, please log on.

Health Economics Review 2011, 1:17  doi:10.1186/2191-1991-1-17

The electronic version of this article is the complete one and can be found online at: http://www.healtheconomicsreview.com/content/1/1/17

Received:6 June 2011
Accepted:26 October 2011
Published:26 October 2011

© 2011 Wolfenstetter and Wenig; licensee Springer.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This literature review aims to analyse the costing methodology in economic analyses of primary preventive physical activity programmes. It demonstrates the usability of a recently published theoretical framework in practice, and may serve as a guide for future economic evaluation studies and for decision making.

A comprehensive literature search was conducted to identify all relevant studies published before December 2009. All studies were analysed regarding their key economic findings and their costing methodology.

In summary, 18 international economic analyses of primary preventive physical activity programmes were identified. Many of these studies conclude that the investigated intervention provides good value for money compared with alternatives (no intervention, usual care or different programme) or is even cost-saving. Although most studies did provide a description of the cost of the intervention programme, methodological details were often not displayed, and savings resulting from the health effects of the intervention were not always included sufficiently.

This review shows the different costing methodologies used in the current health economic literature and compares them with a theoretical framework. The high variability regarding the costs assessment and the lack of transparency concerning the methods limits the comparability of the results, which points out the need for a handy minimal dataset of cost assessment.

Economics; Costs and Cost Analyses; Motor Activity; Primary prevention; Intervention Studies


The prevalence of physical inactivity among adults is increasing worldwide. Several diseases such as diabetes mellitus type 2, dyslipoproteinaemia and cardiovascular disease are associated with overweight and physical inactivity [1]; therefore, prevention of physical inactivity is one of the WHO's European regional targets [2]. A positive correlation between physical activity and positive psychological, physiological as well as social effects was found in many reviews and meta-analyses with a focus on secondary prevention. Furthermore, physical activity interventions are shown to be clinically effective [3,4]. Data on the cost-effectiveness of physical exercise intervention programmes is needed to base decisions on possible implementation and transferability on valid information. There are many reviews concerning the cost-effectiveness of secondary prevention programmes that include physical exercise as a treatment option [5,6]. Earlier reviews examined the economic results of preventive physical activity programmes without differentiation of primary and secondary prevention [7-9]. One recent review evaluated the economic evidence and transferability of physical activity interventions in primary prevention. This study concluded that the level of economic evidence as well as the transferability and comparability of cost-effectiveness results are limited because of differences in the methodology used and a lack of transparency [10]. The results of cost-effectiveness studies primarily depend on the cost components included in the calculation. Nevertheless, all of the existing reviews concentrated on the summary of findings and none of the studies analysed the applied costing methodologies in detail.

This present literature review aims to fill this gap by providing an in-depth analyses of the cost assessment of economic analyses of primary preventive physical activity programmes using similar review techniques as in our previous review article [10]. It thereby demonstrates the usability of a theoretical framework which is based on different well established methods and guidelines and specifically adapted for economic evaluations of primary preventive physical activity programmes [11]. Furthermore, the conclusions drawn may serve as a guide for future economic evaluation studies in this field.

Materials and methods

Search process

The databases PubMed/Medline were searched for all possible combinations of three groups of terms in order to identify all relevant studies published before December 2009: The first group broadly described different methods of economic evaluation: 'Costs and Cost Analysis' OR 'Economics'. The second group included different terms assigned to physical activity: 'Movement' OR 'Exercise Therapy' OR 'Exercise Test' OR 'Exercise Movement Techniques' OR 'Exercise Tolerance' OR 'Exercise'. The third group contained terms for prevention: 'Prevention and Control' OR 'Primary Prevention' OR 'Health Promotion' OR 'Accident Prevention' OR 'Centres for Disease Control and Prevention (U.S.)'.

Most of the selected MeSH terms are generic terms, each encompassing a set of subordinate search words. Thus, the search for 'cost-benefit analysis', for example, is covered by the search for 'costs and cost analysis' (MeSH). Similarly, 'motor/physical activity' is assigned to the MeSH term 'movement'. Additional searches in the DIMDI, EconLit and Embase databases were carried out analogously. Based on the assessment of the abstracts, a list of relevant papers was derived. Papers were deemed potentially relevant if the outcomes and costs of a primary prevention physical activity programme were evaluated.

Inclusion and exclusion criteria

Only studies published in peer-reviewed scientific journals in English, Dutch, French and German before December 2009 were considered for this review. This review is limited to trial-based economic analyses of primary research focusing on an adult population. This type of study has a high priority for the German Institute for Quality and Efficiency in Health Care (IQWiG) providing strong and convincing evidence of efficacy [12]. For the purpose of this review, studies based on secondary research, literature-based modelling and literature reviews were excluded, because they are based on cost data from other studies and not on original cost assessment. Reported findings were not included if they were anecdotal and/or not evaluated. The present review is limited to economic analyses reporting the costs or cost-effectiveness of primary prevention programmes based on physical exercise.

Data extraction and criteria

In total, 949 studies resulted from the first search in PubMed, including all studies that were completed before December 2009. Five studies were excluded due to the language limitation. Many of the 944 studies left were secondary prevention studies, observation studies or only covered effectiveness. Others were reviews, focused on children or not peer reviewed, and were thus excluded from further examination. As suggested by the PRISMA-guidelines [13], Figure 1 illustrates the flow of information through the different phases of this literature review. Even though literature search and assessment of the costing methodology followed a systematic approach, this is not a classical systematic review according to PRISMA-guidelines as the focus was rather on highlighting the diversity in cost assessment of existing economic evaluations rather than the assessment of their quality, which has been analysed elsewhere [10]. Eighteen of the finally selected primary research studies described an economic analysis of physical activity programmes for adults. Additional searches in the DIMDI, EconLit and Embase databases showed no further relevant results. Data extraction regarding cost assessment methodology follows a previously published theoretical framework for economic evaluation of physical activity programmes. Data extraction was undertaken and checked by two researchers individually reaching agreement after discussion in all 18 studies.

thumbnailFigure 1. Flow of information through the different phases of the literature review (Moher et al., 2009).

Study characteristics and key economic findings

All the 18 studies included were briefly described regarding important characteristics, including 'type of physical exercise intervention, comparator, length of intervention, data collection, study population, country, setting, year(s) of the study, study design, type of economic evaluation'and key economic findings. In order to facilitate comparisons across studies, costs were converted to Euros using purchasing power parities (PPP) [14] if available. These results were inflated to 2008 prices using general price indices (GDP) [15]. In case the information on the base year for prices was missing, the year of the intervention was assumed instead, if indicated.

Cost assessment

The cost assessment of this review refers to a conceptual framework developed by Wolfenstetter [11] which is based on different well established methodological guidelines and specifically adapted for economic evaluations of primary preventive physical activity programmes. According to this framework, the cost dimension include programme development costs and programme implementation costs (consisting of recruitment costs, programme costs and time costs of participants), and cost savings due to health effects of the intervention. These cost savings consist of direct medical costs, direct non-medical costs and indirect costs.

Programme development costs include costs for initiating and developing a physical activity programme. The importance of this cost category greatly depends on the aims of the decision-maker, for example whether the whole programme had to be adapted to a different target group and/or setting.

The second cost category comprises the programme implementation costs, which include personnel and non-personnel costs resulting from the intervention programme and the recruitment of participants as well as participant time costs. Recruitment costs contain costs that are linked to the recruitment of participants, for example marketing and advertising activities. These activities are considered in the health economic evaluation in terms of, for example, personnel time costs, costs for posters, flyers or a pilot workout. Most studies are economic evaluation of trials. However, the recruitment costs included should mimic the costs of recruiting people for the programme in a real world setting as far as possible.

The programme costs are costs directly associated with the consumption of resources necessary for carrying out the programme and include, for example, personnel expenditures for instructors and trainers, non-personnel costs, like for sports equipment or costs for the gym. The programme related time costs of participants should be analysed and valued according to the principle of opportunity cost. Valuation should depend on whether the time for physical exercise replaces leisure time or labour time. Similar to productivity losses due to illness, lost labour time due to participation in prevention programmes could be valued using the human capital or friction cost approach. Yet, research protocol driven participant time costs should not be included because time spent in a research study will differ from time spend for participation in a real community physical activity programme.

The incremental cost-effectiveness ratio is calculated based on the resulting net costs and the health effect of the programme.

The cost savings are composed of direct medical costs, direct non-medical costs and indirect costs depending on the chosen perspective. Although a societal perspective requires the inclusion of all direct and indirect costs, the company perspective might focus on indirect costs resulting from sick leave, and the healthcare payer perspective on the cost components they have to reimburse, primarily direct medical costs. Direct medical costs are costs associated directly with the utilisation of healthcare services, for example physician contacts, medication, hospitalisation, rehabilitation, remedies, aids and also over-the-counter medication. They can also include patients' out-of-pocket expenses. The level of aggregation of the costs also depends on the availability of data on costs. Direct non-medical costs include costs such as expenditures for additional health programmes, costs of transportation or information costs.

Indirect costs comprise costs of illness-related absenteeism from paid work (short- and long-term absence from work) as well as from unpaid work (e.g. housework), and costs of productivity loss or gain due to morbidity or premature mortality. Indirect costs will only be included if a societal or company perspective is chosen.

Health effects of health promotion programmes and a corresponding cost reduction could occur with a long time delay. Most individuals appear to have a positive rate of time preference, i.e. a preference to enjoy benefits today more than in the future and, conversely, favour paying costs in the future rather than today. Thus, Smith and Gravelle recommended the need for discounting if the evaluation takes more than 18 months [16]. The practice of the chosen discount rate depends on country-specific recommendations [12,17,18].

A high level of detail in reporting of resource use has to be aimed for as well as exact description of the valuation methods.

This article presents an overview of the different cost categories that were assessed in the 18 reviewed studies. Additionally, important methodological issues such as price year and valuation method, presentation of physical units, perspective, discount rate and the existence of a sensitivity analysis are presented.


Study characteristics and key findings

Altogether, 18 economic analyses of physical activity programmes in primary prevention from seven different countries (Taiwan, UK, New Zealand, Netherlands, Canada, USA and Australia) were identified. All were published in English between 1982 and 2008. Table 1 summarises the study characteristics and Table 2 offers an overview on the key economic findings.

Table 1. Study characteristics

Table 2. Key economic findings

There was a great variation in the type (e.g., supervised and unsupervised physical activity) and length (10 weeks-12 years) of physical exercise programme as well as the adult study populations (e.g., all ages or 80 years and older) in the reviewed interventions. The outcomes varied from specific measures, for example activity change or health events (falls), to generic measures, such as quality-adjusted life-years (QALYs) or disability-adjusted life-years (DALYs). Moreover, the authors of the analysed studies considered different types of economic analyses. Owing to different outcome parameters, the comparison of the results between studies is not possible in all cases. To facilitate comparison of the study results Tables 1 and 2 are organised first according to the type of economic evaluation and second according to the central outcomes.

Cost assessment

Programme development costs have only been itemised in two of the 18 studies [19,20] and mentioned in one [21]. Recruitment costs were explicitly assessed and disclosed in three studies in terms of, for example, invitations, reminders and marketing (TV/newspaper) [22-24]. Robertson et al. included recruitment costs in total programme costs [25-27] and one further study only mentioned these costs [21]. Programme costs were explicitly disclosed in all but six studies [28-33]. The contents of the programme costs vary considerably, primarily depending on the accuracy of the reporting and the type of programme.

Chen et al. included lost income for the participant and his/her companion due to the intervention [34]. Two studies valued these costs as zero [26,27]. As most studies did not include this component, they apparently assumed exercise to be part of leisure time.

Direct medical costs were included in nine studies [20,25-28,30-33] predominantly appropriate to their chosen perspective if stated. Direct non-medical costs were only collected by one study in terms of costs of additional exercise [20]. Five studies assessed sick leave days or hours [20,21,23,32,35], but only two cost studies calculated indirect costs appropriate to their chosen perspective, the societal or company perspective [20,21]. Robertson and colleagues have chosen a societal perspective and did not include direct non-medical costs as well as indirect costs in their calculation, as all their participants were older than 75 years [25-27]. The contents of health savings vary greatly among the reviewed studies, primarily depending on the perspective, but also on the availability of data, the study population and the accuracy of the reporting.

Important methodological aspects

Three of the reviewed studies discounted future costs with a 5% rate according to their time of intervention including the follow-up period [19,20,36]. Six studies evaluated a physical activity programme over a period of 18 months and discounted neither costs nor effects [23,25,28,29,33,35].

A separate and transparent presentation of how the quantities of resource use were determined was found in more than half the reviewed studies, which improves the traceability of the cost assessment. In many studies, the physical units consumed are monetised with market prices reflecting opportunity costs, and personnel time was valued by average wage rates as recommended [37,38]. Other studies refer to financial records and statistics, for example from insurances or from hospitals for cost estimation [25,30-32]. One study did not reveal the methodology of valuation at all [29]. All costs were declared in their own country's currency. Eight studies did not explicitly state the price year of adjustment [19,21,22,24,29,33,34,36], which impedes the transferability of the results. Sensitivity analysis can be used to examine the uncertainty related to key assumptions in the calculation of costs, for example in calculating different rents for gyms or tariffs for physical exercise trainers [39]. Seven studies did not conduct sensitivity analyses for the costs or the effects of the intervention under review [29-35]. The assessments of all cost categories and methodological aspects are summarised in Table 3.

Table 3. Costing in economic analyses of physical activity programmes in primary prevention

The problems of comparing economic evaluations of primary prevention programmes mainly refer to the intervention and its context specific aims as well as the purpose of the decision-maker and his/her options. The decision-maker determines the perspective, which has to be chosen carefully and stated explicitly, as it defines the cost categories that have to be included in the cost analysis. The patient perspective reduces the relevant costs to out-of-pocket expenses and lost time in both programme costs (e.g. programme fees, lost leisure time) and savings (e.g. out-of-pocket expenses for pharmaceuticals, indirect costs regarding unpaid work). Only Elley et al. considered the patient perspective next to the healthcare payer and societal perspective in their calculations [20]. The indirect costs due to absenteeism are the main savings resulting from health effects from a company perspective, which was chosen in two analyses [21,35]. Both studies included programme costs and examined the costs of sick leave. The healthcare payer perspective was solely chosen by three studies, which would require the inclusion of programme implementation costs as well as direct (non)-medical costs that have to be reimbursed by health insurance. Baun et al. only regarded the direct medical costs compared with no intervention. Sevick et al. only considered programme costs and did not include direct medical costs even though they took a healthcare payer and provider perspective [32,36]. Munro et al. include both categories in their calculation [23]. The most recommended societal perspective requires a comprehensive assessment of programme implementation costs and all categories of savings due to health effects. Only four of the reviewed studies chose the societal perspective [20,25-27]. Thus, they include healthcare savings as well as detailed programme implementation components. Nine studies did not clearly state their chosen perspective and only included parts of the cost components. Even if most studies did provide at least a rough description of included cost components, the level of detail differed substantially, for example equipment or administration and what it included. Table 4 presents an overview of recommendations for the minimal basic datasets depending on the chosen perspective. The single cost items refer to the detailed description in the 'materials and methods' section and in Wolfenstetter 2011 [11].

Table 4. Minimal basic datasets depending on the chosen perspective

Discussion and conclusion

In sum, 18 international economic analyses of primary preventive physical activity programmes were identified and analysed regarding their key economic findings and their costing methodology. Most of the reviewed studies deduce that the investigated intervention is good value for money compared with alternatives or even cost saving. However, these results are difficult to compare, mainly because of methodological differences, for example the type of economic evaluation, regarded outcomes, included cost components (depending on the chosen perspective) or the valuation of utilisation.

As the inclusion of cost variables such as for gym hire, equipment and the salaries of site health personnel are not standardised, decision-makers confronted with the question of whether or not to transfer and implement the programme need to be fully informed about the cost items included in the total programme costs. For the economic evaluation of physical activity programmes not only components of the programme costs, but also potential savings due to health effects (i.e. direct and indirect costs) should be included in the costs calculation. For the assessment of all cost components, it is also important that the utilisation in physical units as well as the methodology of valuation are described in detail. Even if most studies did provide a detailed description of the costs of the intervention programme in their country currency, data on the underlying quantities of resources used, discounting/inflation methods and the price year were often not displayed, thus making comparability difficult. Sensitivity analyses should be calculated to clarify uncertainty related to key assumptions. However, the main areas of uncertainty were often not considered in the studies, or sensitivity analyses were of low quality, for example insufficient explanation was given for the range of parameters chosen for the sensitivity analysis.

Costs and cost savings also depend on the time horizon of the evaluation. In the case of physical activity programmes, savings of health service resources emerge as a consequence of reductions in inactivity-related diseases and mortality, leading to a lower utilisation of healthcare services and lower productivity losses [40]. Furthermore costs and cost savings can differ between age-groups and gender, for example costs of productivity losses. This should be considered depending on the chosen study population.

Of course, medical outcome parameters are often more important than the costs of a programme. However, in times of budget restraints, costs gain more and more importance.

The results of cost-effectiveness studies primarily depend on the cost components included and the comparability of the results is difficult if cost assessment differs substantially. Although an earlier review evaluated the economic evidence and transferability of physical activity interventions in primary prevention [10], to our knowledge, none of the already existing reviews in this area analysed the applied costing methodologies in detail. This present literature review aims to fill this gap by providing an in-depth analysis of the cost assessment of economic analyses of primary preventive physical activity programmes as well as a minimal dataset for cost assessment depending on the chosen perspective as a practical guide for the economic evaluation of physical activity programmes. Further methodological problems and more detailed recommendations for the economic evaluations of primary preventive physical activity programmes are comprehensively explained and discussed elsewhere [7,10,41].

The main limitations of this review are that the search was limited to those publications referenced in the given databases; only English, German, French and Dutch papers were considered. However, this excluded only three Japanese and two Spanish studies listed in PubMed. The selection and analysis of the studies was conducted by only two researchers reaching concordance after discussion in all cases but still leaving room for a possible bias. The costs of the studies were adjusted to Euros (2008), if possible, to show better comparability between the study results. However, the explanatory power is limited because country-specific healthcare systems, their prices and charges, etc. were neglected in this calculation.

This review targets clinicians, behavioural scientists, researchers working in the field of public health and decision-makers. It may, to some degree, demonstrate the difficulties of economic evaluation in the area of primary prevention. It aims to provide useful information for researchers, asking which perspective has to be chosen and which cost components have to be assessed for the evaluation to provide an optimal database for decision-making.

There is a gap between theoretical guidelines for cost assessment and their application in practice. One reason is that the chosen costing methods are often greatly dependent on the available data. This review shows that there is little standardisation of what constitute costs in such interventions and their evaluations. The comparability of the cost-effectiveness results of physical activity programmes is problematic on different levels: first, the examined programmes vary considerably in their aims and characteristics suited to their specific context and study population. Second, the methodologies used are often not revealed transparently and, third, if comprehensibly described, the methods and accuracy of reporting differ substantially. In order to generalise the results to other settings, regions or countries, a country-specific adaptation is necessary to account for, for example, different inactivity prevalence, healthcare system characteristics and absolute and relative prices. Recommendations for transferability of study results are given by Welte et al. [42].

In general, the high variability of the costing methods between the studies limits comparability and generalisability. However, the need to identify cost-effective or cost-saving prevention programmes and to transfer study results from one region or country to another is growing. To improve the standardisation and comparability of economic evaluations among different physical activity programmes and among countries, high methodological quality and explicit reporting of a minimal dataset are important, which is a big challenge for health economists.

Conflict of interests

The authors declare that they have no competing interests.

Authors' contributions

The databases PubMed/Medline were searched by SBW for all possible combinations of three groups of terms in order to identify all relevant studies published before December 2009. Data extraction and assessment were undertaken and checked by SBW and CMW. SBW and CMW analysed the data and interpreted the results. Both authors drafted the manuscript, read and approved the final version of the manuscript.


The investigation was supported by the Federal Ministry of Education and Research within the Competence Network of Obesity Research [Project: MEMORI: Multidisciplinary Early Modification of Obesity Risk (Grant: 01GI0826)]. The authors wish to thank especially R. Leidl and J. John for their valuable support (both at LMU Muenchen - Institute for Health Economics and Health Care Management).


  1. Konig D, Bonner G, Berg A: [The role of adiposity and inactivity in primary prevention of cardiovascular disease].

    Herz 2007, 32:553-559. PubMed Abstract | Publisher Full Text OpenURL

  2. Physical activity [http://www.who.int/dietphysicalactivity/en/] webcite

    World Health Organization (WHO): Global Strategy on Diet, Physical Activity and Health. OpenURL

  3. Karmisholt K, Gyntelberg F, Gotzche PC: Physical activity for primary prevention of disease. Systematic reviews of randomised clinical trials.

    Dan Med Bull 2005, 52:86-89. PubMed Abstract OpenURL

  4. Gardner MM, Robertson MC, Campbell AJ: Exercise in preventing falls and fall related injuries in older people: a review of randomised controlled trials.

    Br J Sports Med 2000, 34:7-17. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  5. Avenell A, Broom J, Brown TJ, Poobalan A, Aucott L, Stearns SC, Smith WC, Jung RT, Campbell MK, Grant AM: Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement.

    Health Technol Assess 2004, 8:iii-iv.


    PubMed Abstract | Publisher Full Text OpenURL

  6. Kouris-Blazos A, Wahlqvist ML: Health economics of weight management: evidence and cost.

    Asia Pac J Clin Nutr 2007, 16(Suppl 1):329-338. PubMed Abstract OpenURL

  7. Hagberg LA, Lindholm L: Is promotion of physical activity a wise use of societal resources? Issues of cost-effectiveness and equity in health.

    Scand J Med Sci Sports 2005, 15:304-312. PubMed Abstract | Publisher Full Text OpenURL

  8. NICE Rapid review of the economic evidence of physical interventions [http:/ / http:/ / www.nice.org.uk/ nicemedia/ pdf/ Physical_Activity_Economic_Review_A pril2006.pdf] webcite

    National Institute for Health an Clinical Excellence (NICE): Rapid review of the economic evidence of physical interventions OpenURL

  9. Shepard RJ: Current Perspectives on the Economics of Fitness and Sport with Particular Reference to Worksite Programmes.

    Sports Med 1989, 7:286-309. PubMed Abstract | Publisher Full Text OpenURL

  10. Wolfenstetter SB, Wenig CM: Economic Evaluation and Transferability of Physical Activity Programmes in Primary Prevention: A Systematic Review.

    Int J Env Res Public Health 2010, 7:1622-1648. Publisher Full Text OpenURL

  11. Wolfenstetter S: Conceptual framework for standard economic evaluation of physical activity programmes in primary prevention.

    Prevention Science 2011.

    Online First 19 Juli 2011


  12. Institute for Quality and Efficiency in Health Care (Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG)): Allgemeine Methoden, Entwurf für Version 3.0 vom 15.11.2007 [in German]. In Book Allgemeine Methoden, Entwurf für Version 3.0 vom 15.11.2007 [in German]. City: Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG); 2007.

    (Editor ed.^eds.)


  13. Moher D, Liberati A, Tetzlaff J, Altman DG: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

    J Clin Epidemiol 2009, 62:1006-1012. PubMed Abstract | Publisher Full Text OpenURL

  14. Purchasing Power Parities (PPP) [http://www.oecd.org/department/0,3355,en_2649_34357_1_1_1_1_1,00.html] webcite

    Organisation for Economic Co-operation and Development (OECD): Purchasing Power Parities (PPP). OpenURL

  15. Consumer Prize Indices [http://stats.oecd.org/wbos/default.aspx] webcite

    Organisation for Economic Co-operation and Development (OECD): Consumer Prize Indices. OpenURL

  16. Smith DH, Gravelle H: The practice of discounting in economic evaluations of healthcare interventions.

    Int J Technol Assess Health Care 2001, 17:236-243. PubMed Abstract | Publisher Full Text OpenURL

  17. Graf von der Schulenburg JM, Greiner W, Jost F, Klusen N, Kubin M, Leidl R, Mittendorf T, Rebscher H, Schoeffski O, Vauth C, et al.: German recommendations on health economic evaluation: third and updated version of the Hanover Consensus.

    Value Health 2008, 11:539-544. PubMed Abstract | Publisher Full Text OpenURL

  18. National Institute for Clinical Excellence (NICE): Guideline Development Methods: Information for National Collaborating Centres and Guideline Developers. In Book Guideline Development Methods: Information for National Collaborating Centres and Guideline Developers. City: National Institute for Clinical Excellence; 2004.

    (Editor ed.^eds.)


  19. Dzator JA, Hendrie D, Burke V, Gianguilio N, Gillam HF, Beilin LJ, Houghton S: A randomized trial of interactive group sessions achieved greater improvements in nutrition and physical activity at a tiny increase in cost.

    J Clin Epidemiol 2004, 57:610-619. PubMed Abstract | Publisher Full Text OpenURL

  20. Elley R, Kerse N, Arroll B, Swinburn B, Ashton T, Robinson E: Cost-effectiveness of physical activity counselling in general practice.

    N Z Med J 2004, 117:U1216. PubMed Abstract OpenURL

  21. Proper KI, de Bruyne MC, Hildebrandt VH, van der Beek AJ, Meerding WJ, van Mechelen W: Costs, benefits and effectiveness of worksite physical activity counseling from the employer's perspective.

    Scand J Work Environ Health 2004, 30:36-46. PubMed Abstract | Publisher Full Text OpenURL

  22. Stevens W, Hillsdon M, Thorogood M, McArdle D: Cost-effectiveness of a primary care based physical activity intervention in 45-74 year old men and women: a randomised controlled trial.

    Br J Sports Med 1998, 32:236-241. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  23. Munro JF, Nicholl JP, Brazier JE, Davey R, Cochrane T: Cost effectiveness of a community based exercise programme in over 65 year olds: cluster randomised trial.

    J Epidemiol Community Health 2004, 58:1004-1010. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  24. Finkelstein EA, Troped PJ, Will JC, Palombo R: Cost-effectiveness of a cardiovascular disease risk reduction program aimed at financially vulnerable women: the Massachusetts WISEWOMAN project.

    J Womens Health Gend Based Med 2002, 11:519-526. PubMed Abstract | Publisher Full Text OpenURL

  25. Robertson MC, Devlin N, Scuffham P, Gardner MM, Buchner DM, Campbell AJ: Economic evaluation of a community based exercise programme to prevent falls.

    J Epidemiol Community Health 2001, 55:600-606. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  26. Robertson MC, Gardner MM, Devlin N, McGee R, Campbell AJ: Effectiveness and economic evaluation of a nurse delivered home exercise programme to prevent falls. 2: Controlled trial in multiple centres.

    BMJ 2001, 322:701-704. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  27. Robertson MC, Devlin N, Gardner MM, Campbell AJ: Effectiveness and economic evaluation of a nurse delivered home exercise programme to prevent falls. 1: Randomised controlled trial.

    BMJ 2001, 322:697-701. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  28. Ackermann RT, Williams B, Nguyen HQ, Berke EM, Maciejewski ML, LoGerfo JP: Healthcare cost differences with participation in a community-based group physical activity benefit for medicare managed care health plan members.

    J Am Geriatr Soc 2008, 56:1459-1465. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  29. The Writing Group for Activity Counselling Trail Research Group: Effects of physical activity counselling in primary care: the Activity Counselling Trial: a randomized controlled trial.

    JAMA 2001, 286:677-687. PubMed Abstract | Publisher Full Text OpenURL

  30. Shephard RJ, Corey P, Renzland P, Cox M: The impact of changes in fitness and lifestyle upon health care utilization.

    Can J Public Health 1983, 74:51-54. PubMed Abstract OpenURL

  31. Shephard RJ, Corey P, Renzland P, Cox M: The influence of an employee fitness and lifestyle modification program upon medical care costs.

    Can J Public Health 1982, 73:259-263. PubMed Abstract OpenURL

  32. Baun WB, Bernacki EJ, Tsai SP: A preliminary investigation: effect of a corporate fitness program on absenteeism and health care cost.

    J Occup Med 1986, 28:18-22. PubMed Abstract | Publisher Full Text OpenURL

  33. Ackermann RT, Cheadle A, Sandhu N, Madsen L, Wagner EH, LoGerfo JP: Community exercise program use and changes in healthcare costs for older adults.

    Am J Prev Med 2003, 25:232-237. PubMed Abstract | Publisher Full Text OpenURL

  34. Chen IJ, Chou CL, Yu S, Cheng SP: Health services utilization and cost utility analysis of a walking program for residential community elderly.

    Nurs Econ 2008, 26:263-269. PubMed Abstract OpenURL

  35. Shephard RJ: Long term impact of a fitness programme--the Canada Life Study.

    Ann Acad Med Singapore 1992, 21:63-68. PubMed Abstract OpenURL

  36. Sevick MA, Dunn AL, Morrow MS, Marcus BH, Chen GJ, Blair SN: Cost-effectiveness of lifestyle and structured exercise interventions in sedentary adults: results of project ACTIVE.

    Am J Prev Med 2000, 19:1-8. PubMed Abstract | Publisher Full Text OpenURL

  37. Brouwer W, Rutten F, Koopmanschap M: Costing in economic evaluations. In Economic evaluations in Health Care - Merging theory with practice. Edited by Drummond MF, McGuire A. Oxford, New York Oxford University Press; 2001. OpenURL

  38. Krauth C, Hessel F, Hansmeier T, Wasem J, Seitz R, Schweikert B: [Empirical standard costs for health economic evaluation in Germany - a proposal by the working group methods in health economic evaluation].

    Gesundheitswesen 2005, 67:736-746. PubMed Abstract | Publisher Full Text OpenURL

  39. Gold MR, Russell LB, Siegel JE: Cost-effectiveness in health and medicine. 1st edition. New York: Oxford University Press; 1996. OpenURL

  40. Haycox A: A methodology for estimating the costs and benefits of health promotion.

    Health Prom Int 1994, 9:5-11. Publisher Full Text OpenURL

  41. Drummond MF, Sculpher M, Torrance GW, O'Brien BJ, Stoddart GL: Methods for Economic Evaluation of Health Care Programmes. 3rd edition. Oxford, New York Oxford University Press; 2005. OpenURL

  42. Welte R, Feenstra T, Jager H, Leidl R: A decision chart for assessing and improving the transferability of economic evaluation results between countries.

    PharmacoEcon 2004, 22:857-876. Publisher Full Text OpenURL

  43. The Writing Group for Activity Counselling Trail Research Group: Effects of physical activity counseling in primary care: the Activity Counseling Trial: a randomized controlled trial.

    The Journal of the American Medical Association 2001, 286:677-687. Publisher Full Text OpenURL